Introduction of an Oxidation-responsive 4-Boronobenzyl Group into an Oligonucleotide through a Postmodification Approach
نویسندگان
چکیده
Oxidation-responsive oligonucleotides (ONs) can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. Herein, we describe a postmodification approach to constructing an oxidation-responsive ON that takes advantage of the reactivity diazo compounds introducing 4-boronobenzyl group phosphate at 5′-terminal ON. We
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 2021
ISSN: ['0366-7022', '1348-0715']
DOI: https://doi.org/10.1246/cl.210204